supported by the National Key Research and Development Program of China(2019YFE0120800 and 2019YFA0111600);the National Natural Science Foundation of China for Innovative Research Group Project(82221002,82130090,81874242,31800979,and 82073145);the Natural Science Foundation of China for Outstanding Young Scholars(82022060);the Natural Science Foundation of Hunan Province for Outstanding Young Scholars(2019JJ30040);Talent Young Scholars of Hunan Province(2019RS2009)。
Melanoma,a type of skin malignancy with a high incidence and poor prognosis,is a global public health issue.The tumorigenesis and pathogenesis of melanoma involve genetic mutations,metabolic disruption,and immune evas...