MCM5和Ki-67在非小细胞肺癌组织中的表达及意义  

Expression of minichromosome maintenance protein 5 and Ki-67 in NSCLC and its significance

作　　者：刘振峰[1] 刘建英[2] 郑洪[3] 邱丹[2] 

机构地区：[1]遵义医学院,贵州遵义563003 [2]遵义医学院第三附属医院 [3]遵义医学院附属医院

出　　处：《山东医药》2008年第5期6-8,共3页Shandong Medical Journal

摘　　要：目的探讨微染色体维持蛋白5(MCM5)和Ki-67在非小细胞肺癌(NSCLC)发生中的作用及机制。方法采用免疫组化EnVision二步法检测MCM5和Ki-67在50份NSCLC组织中的表达,并分析其与NSCLC临床病理特征的关系。结果NSCLC组织MCM5、Ki-67表达水平均高于肺良性病变组织和不典型增生组织;MCM5表达明显高于Ki-67,两者表达呈正相关;MCM5的表达与肿瘤分化程度、淋巴结转移、临床病理分期和核分裂指数显著相关(P均<0.005),与患者年龄及组织学类型无明显相关性。结论MCM5在NSCLC的发生、发展中起重要作用,其作为NSCLC病理诊断的参考指标较Ki-67有更强的敏感性。Objective To study the relationship between minichromosome maintenance protein 5(MCM5)expression and clinical pathological characteristics of non-small cell lung cancer(NSCLC),and to analyze the correlation between MCM5 and Ki-67.Methods The expression of MCM5 and Ki-67 were detected with immunohistochemical Evision technique.Results The expressions of MCM-5 and Ki-67 were both higher in cancer than those in tissues of benign lung and non-typical hyperplasia,and the labeling index of MCM5 was higher than th...

关 键 词：非小细胞肺癌 微染色体维持蛋白5 KI-67 

分 类 号：R734.2[医药卫生—肿瘤]