抑癌基因ING1蛋白在早期肺癌组织中的表达及意义  

Expression and its clinical signification of anti-oncogene ING1 in early-stage lung carcinoma tissues

作　　者：曾凡军[1] 丁文柏[1] 陈世雄[1] 徐新娟[1] 周媛媛[1] 罗代珍[1] 夏道奎[1] 张春芳[1] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院,湖北宜昌443003

出　　处：《山东医药》2008年第5期9-11,共3页Shandong Medical Journal

基　　金：宜昌市科技局资助项目(A06405)

摘　　要：目的研究抑癌基因ING1的蛋白表达产物p33ING1在肺癌发生、发展中的作用。方法用免疫组化SP法检测p33ING1在40例肺癌和10例正常肺组织中的表达。结果p33ING1在肺癌组织中的阳性表达率(57.5%)明显低于正常肺组织(100.0%),P<0.05。p33ING1表达与淋巴结转移、TNM分期及组织分化有关。结论p33ING1低表达在肺癌的发生、发展中可能起重要作用;其对判断肺癌的恶性程度、浸润甚至转移有重要价值。Objective To investigate the expression of p33ING1 that expressed by anti-oncogene ING1,and its relationship with clinic pathology feature in early-stage lung carcinoma tissues;and to explore the possible mechanism of anti-oncogene ING1 in the carcinogenesis of lung carcinoma.Methods Immunohistochemistry staining(labeled streptavidin-biotin method)was used to detect p33ING1 expression in 40 cases with lung carcinoma and 10 cases with normal lung tissues.Results The positive rate of p33ING1 in 40 cases with ...

关 键 词：肺肿瘤 抑癌基因 p33^(ING1) 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]