CCL19/21-CCR7生物学轴与肿瘤转移  

CCL19/21-CCR7 biological axis and cancer metastasis

作　　者：杨银龙[1] 欧周罗[1] 邵志敏[1] 

机构地区：[1]复旦大学附属肿瘤医院乳腺癌研究所,上海200032

出　　处：《国际肿瘤学杂志》2006年第8期564-567,共4页Journal of International Oncology

摘　　要：肿瘤转移有其选择性和特异性,不同组织来源的肿瘤易向某些特定的组织和器官如淋巴结、肺、肝、骨等转移,但人们对其机制知之甚少。近年来,发现不少趋化因子及其受体在肿瘤的转移中扮演重要角色。现就CCL19/21-CCR7生物学轴在肿瘤转移中的作用作一综述。Cancer metastasis presents a highly non-random and organ-selective process.Certain tumors show a metastatic tendency towards specific organs,such as lymph nodes,lungs,livers,bone, and so on.However,we don t have much information of theirt mechanisms.Recently,researches find chemokines and their receptors play important roles in tumors organ-selective metastasis.This article will review the roles of CCL19/21-CCR7 biological axis in cancer metastasis.

关 键 词：炎症趋化因子类 受体 趋化因子 肿瘤转移 

分 类 号：R730.21[医药卫生—肿瘤]