VEGFR-3与肿瘤淋巴转移的研究进展  

Progress in VEGFR-3 and cancer metastasis

作　　者：陈浩[1] 高媛[1] 孙启鸿[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所免疫学研究室,北京100850

出　　处：《免疫学杂志》2006年第z1期29-32,共4页Immunological Journal

基　　金：国家863计划资助项目(2002AA214031)

摘　　要：肿瘤转移通常是人类癌症致死的主要原因之一。淋巴转移是肿瘤特别是癌的常见转移途径,肿瘤细胞转移至淋巴结通常作为肿瘤转移的信号,同时也是患者预后的重要指标。在肿瘤转移过程中,血管内皮生长因子及其受体家族发挥了重要的作用。尤其是淋巴内皮特异性的受体——血管内皮生长因子受体3(VEGFR-3)及其配体VEGF-C/D在促进淋巴管生长具有关键的作用。本文就VEGFR-3与肿瘤淋巴转移的研究进展进行综述。Tumor metastasis is a major cause of death in cancer patients.The lymphatic system is the primary route for metastasis in most human cancer.The existence of tumor cells in lymph nodes(LNs) is a sign that metastatic spread of cancer has occurred,and a key pro-gnostic factor for the patient's outcome.During the processes of cancer cells spreading,vascular endothelial growth factors(VEGFs) and their receptors(VEGFRs) play important roles.In particular,VEGFR-3 and its ligands VEGF-C and VEGF-D play crucial roles in promoting lymphatic vascular growth.This review summarized the recent data on VEGFR-3 in the tumor metastasis.

关 键 词：VEGFR-3 肿瘤转移 肿瘤治疗 

分 类 号：R730.2[医药卫生—肿瘤]