椒目中高纯度α-亚麻酸的提取分离  

Extraction and Isolation of Highly Purified α-linoleic Acid from Bunge Pricklyash Seed

作　　者：杨倩[1] 王庆伟[2] 刘雪英[3] 王四旺[1] 王剑波[1] 谢艳华[1] 

机构地区：[1]第四军医大学药学系药物研究所 [2]第四军医大学唐都医院药剂科 [3]第四军医大学药学系化学教研室,西安710033

出　　处：《天然产物研究与开发》2006年第5期846-847,853,共3页Natural Product Research and Development

基　　金：陕西省中医药管理局资助项目(2005079)

摘　　要：椒目作为一种新的木本油脂资源,其油脂中约含有30%的α-亚麻酸,采用本文创制的综合方法可对其中的α-亚麻酸进行有效分离和纯化,为椒目的综合开发和利用奠定了研究基础。椒目经皂化酸解得游离的混合脂肪酸,依次经梯度冷冻、尿素包合及硝酸银络合,得高纯度α-亚麻酸。经HPLC分析,以本文的方法得到的α-亚麻酸含量高达91.6%以上。Bunge pricklyash seed as a new type ligneous cerolein resource has 30% α-linoleic acid in its cerolein.We can effectively separate the α-linoleic acid from the total by the method of this article,and encourage synthetic exploitation and utilization for bunge pricklyash seed.Saponify and acid hydrolysis bunge pricklyash seed to obtain free and mixed fatty acid.Then it is processd by gradient deepfree,carbamide clathration,and silver nitrate complexation to obtain highly purified α-linoleic acid.According to high performance liquid chromatography analysis,the content of α-linoleic acid gotten by the method of this article has reached above 91.6%.

关 键 词：椒目 Α-亚麻酸 高纯度 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学] Q949.752.7[医药卫生—中医学]