激光免疫疗法——一种新型肿瘤治疗方法  

Laser Immunotherapy.a Novel Modality for Cancer Treatment

作　　者：罗芳洪[1] 曾超英[1] 黄萍[1] 

机构地区：[1]厦门大学医学院抗癌研究中心,厦门市361005

出　　处：《中国激光医学杂志》2006年第5期327-329,共3页Chinese Journal of Laser Medicine & Surgery

摘　　要：激光免疫疗法是一种新型肿瘤治疗方法,治疗过程中包括三个基本要素：激光、光敏剂(光吸收剂)和免疫佐剂。该疗法可通过光化学作用在一定范围内破坏肿瘤组织；免疫佐剂还能诱导机体产生免疫反应,杀灭原发肿瘤和转移瘤,并产生肿瘤特异性免疫力,表现出很好的远期疗效。目前应用于激光免疫治疗的有630、652、671、690和810nm波长激光,光敏剂(光吸收剂)有吲哚菁绿、血卟啉衍生物及酞氰类化合物等,免疫佐剂有糖基化聚氨基葡糖、OK-432、MCWE、福氏佐剂及细胞因子等。Laser immunotherapy is a novel approach for the treatment of cancer,which consists of three components :a laser,a photosensitizer and an immunoadjuvant.Laser immunotherapy combines a selective photochemical interaction for direct tumor destruction and an immuno- adjuvant-directed simulation for the host's immune responses.It results in the eradication of both,treated primary tumors and untreated metastases at remote sites.It can also induce a tumor-specific immunity and demonstrates long-term anti-cancer effect.Presently,laser used in laser immunotherapy includes 630,652,671,690 or 810 nm wave length.Photosensitizer used includes indocyanine green,Pho- tofrin or metatetrahydroxy-phenylchlorin(mTHPC),etc.Immunoadjuvant used includes glycated chitosan,streptococcal preparation OK-432,mycobacterium cell-wall extract(MCWE),Freund's adjuvant or cytokine,etc.

关 键 词：激光免疫疗法 激光 光敏剂 免疫佐剂 

分 类 号：R730.5[医药卫生—肿瘤]