SD大鼠血液学指标和血清生化学指标参考值探讨  

Study of Normal Value Ranges for Hematology and Biochemical Indexes in Male and Female SD Rats

作　　者：马新群[1] 陆丹[1] 陈志莲[1] 吴军[1] 杨秀鸿[1] 李军[1] 熊志军[1] 

机构地区：[1]湖南省劳动卫生职业病防治所,湖南长沙410007

出　　处：《实用预防医学》2006年第6期1467-1468,共2页Practical Preventive Medicine

摘　　要：目的探讨SD大鼠血液学指标和血清生化学指标的参考值。方法收集3个批次雌雄共586只大鼠的17项血液学、血清生化学指标进行统计分析。结果17项指标的平均值及其95%参考值范围的性别差异无显著性；RBC在不同批次的雌雄鼠之间无显著性差异(P＞0．05)。雌鼠WBC、AST的测定值批间差异有显著性(P＜0．05),雄鼠批间差异无显著性。雄鼠ALB、TG的测定值批间差异有显著性(P＜0．05),雌鼠批间差异无显著性。结论SD大鼠亚慢性经口(试验的)17项血液学和血清生化学指标参考值与文献报道一致；并且雌雄鼠可以合并计算。Objective To explore the normal value range variations for hematology indexes and biochemical indexes in serum of male and female SD rats.Methods The data of hematology indexes and biochemical indexes in serum of 586 rats in 3 experiments were collected and statistically analyzed.Results The average value and the 95% normal value range of ?hematology indexes and 10 serum biochemical indexes showed no significant difference between both sexes.No significant difference was found in RBC(P＞0.05).But significant differences were found in WBC and AST in female rats(P＜0.05),and no difference was found in male rats.The ALB and TG of male rats showed significant differences(P＜0.05),but not in fe- male rats.Conclusions The normal value ranges of hematology and serum biochemical indexes in serum of SD rats(be- fore the test)are consistent with those literatures reported,and it is feasible to combine the female and male rat's data during statistical analysis.

关 键 词：大鼠 SD 血液学指标 生化学指标 参考值范围 

分 类 号：R-33[医药卫生]