液基细胞学技术、阴道镜及PTEN和p27基因表达对宫颈癌的诊断意义  

Diagnostic significance of LCT,colposcopy and expression of PTEN and p27 in cervical carcinoma

作　　者：原继荣[1] 张玲[1] 付小萌[1] 肖兵[1] 杜亚丽[1] 

机构地区：[1]哈尔滨医科大学第二附属医院,黑龙江哈尔滨150086

出　　处：《中国现代医学杂志》2006年第24期3777-3780,共4页China Journal of Modern Medicine

摘　　要：目的探讨液基细胞学技术(LCT)、阴道镜、PTEN和p27表达在宫颈癌(IC)早期诊断中的意义。方法对348例疑有宫颈病变者行LCT、阴道镜检查及定位活检;采用免疫组化法对其中28例IC、45例宫颈上皮内瘤样变(CIN)和5例正常宫颈组织行PTEN及p27检测。结果105例LCT异常,占30.17%;68例阴道镜检查异常,占19.54%;73例CINⅠ以上,占20.98%;PTEN和p27表达随IC发展显著下降(P<0.05)。结论结合LCT、阴道镜检查加定位活检和PTEN及p27蛋白表达结果可早期诊断IC。[Objective] To study the diagnostic significance of LCT, colposcopy and expression of PTEN and p27 in cervical carcinoma. [Methods] 348 cases with cervix erosion were examined by LCT, colposcopy and biopsy; 28 cases with invasive carcinoma (IC), 45 cases with cervical intraepithelial neoplasia (CIN) and 5 cases with normal cervical tissuses were examined the expression of PTEN and p27 by immunohistochemical staining. [Results] 105 cases showed positive rate of LCT (30.17%); 68 cases showed positive rate of colposcopy (19.54%); 73 cases showed CIN (20.98%); the expression of PTEN and p27 were decreased significantly from NE, CIN and invasive cervical carcinoma. [Conclusion] LCT, colposcopy and biopsy as well as the expression of PTEN and p27 are very important in early diagnosis of cervical carcinoma.

关 键 词：宫颈癌 LCT 阴道镜 PTEN P27 

分 类 号：R737.33[医药卫生—肿瘤]