吲哚并[3,2-c]喹啉衍生物的微波辅助合成  

Microwave irradiation assisted synthesis of indolo [3,2-c] quinoline derivatives

作　　者：张稳稳[1] 周忠华[1] 曾红[2] 何菱[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学华西口腔医院,四川成都610041

出　　处：《华西药学杂志》2008年第3期263-264,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的合成吲哚并[3,2-c]喹啉衍生物并优化其工艺。方法微波辅助Michael加成、环合、Fischer吲哚合成。结果合成了6个吲哚并[3,2-c]喹啉衍生物。结论微波能缩短反应时间,提高Michael加成和Fischer吲哚合成反应的收率。OBJECTIVE To synthesize and optimize the technical process of indolo quinoline.METHODS Microwave assisted Michael addition,cyclization and Fischer indole synthesis methods were adopted.RESULTS 6 kinds of indolo quinoline derivatives were synthesized.CONCLUSION A rapid method for the synthesis of indolo quinoline has been developed under microwave irradiation.The method can not only improve the yields,but also simplify the reaction process.

关 键 词：微波辅助合成 MICHAEL加成 Fischer吲哚合成 吲哚并[3 2-c]喹啉 β-苯基萘型化合物 

分 类 号：R914[医药卫生—药物化学]