MMP9和CD147在乳腺癌的表达及意义  

The Expression and Its Significances of MMP9 and CD147 Protein in Breast Cancer

作　　者：侯志斌[1] 郭新建[2] 

机构地区：[1]青海省西宁市第二人民医院病理科,810003 [2]青海大学医学院附属医院病理科,810001

出　　处：《青海医药杂志》2008年第3期9-11,共3页Qinghai Medical Journal

摘　　要：目的:探讨基质金属蛋白酶-9(MMP9)和CD147在乳腺癌中的表达及意义。方法:应用免疫组化染色S-P法,检测88例乳腺癌组织石蜡切片中MMP9及CD147的表达情况。结果:乳腺癌患者MMP9的表达与肿瘤的分级、大小无明显关系,与淋巴转移有明确相关联系(P<0.05)。CD147与病理分级、淋巴结转移的表达呈显著性正相关(P<0.05)。结论:CD147和MMP9相互影响参与了乳腺癌的侵袭与转移,两种物质的检测是判断乳腺癌预后与治疗的重要指标之一。Objective:To observe the expression and its significances of MMP9 and CD147 protein in breast cancer. Methods:Expression of MMP9 and CD147 protein in 88 patients with breast cancer was measured by immunohistochemistry (S-P) method. Results:Expression of MMP9 protein positively correlate with lymph node metastasis (P<0.05) but there was no relation to tumor grades and tumor size (P>0.05).The correlation existed between expression of CD147 protein and tumor grades and lymph node metastasis (P<0.05).C...

关 键 词：基质金属蛋白酶-9(MMP9) CD147 乳腺癌 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]