HPB方案在宫颈鳞癌新辅助化疗中的应用  

Neoadjuvant chemotherapy of cisplatin combined with hydroxycamptothecine、bleomycin regimen in squamous carcinoma of uterine cervix

作　　者：王莉[1] 刘风花[1] 寇歆馨[1] 

机构地区：[1]河南省肿瘤医院妇瘤科,河南郑州450008

出　　处：《河南医学研究》2008年第1期38-42,共5页Henan Medical Research

摘　　要：目的:通过研究证明HPB方案(羟基喜树碱HCPT、顺铂DDP、博莱霉素BLM)是宫颈鳞癌新的、有效的新辅助化疗方案。方法:用HPB方案对107例宫颈鳞癌Ⅰb~Ⅱb期病人进行新辅助化疗,观察化疗前后宫颈肿瘤体积变化及病理组织学化疗反应分级,双重判断化疗效果。比较化疗后手术与直接手术患者术后并发症的发生情况。与国外常用化疗方案B IP比较化疗的毒副作用。用流式细胞术检测和分析化疗前后宫颈癌组织中增殖细胞核抗原(PCNA)、K i-67表达的变化及化疗前CD44v6的表达。用TUNEL法检测化疗前后肿瘤细胞的调亡指数(AI)。结果:巨块型宫颈癌的显效率(CR+PR)为71.43%,总有效率(CR+PR+SD)为98.41%。进一步研究的显效率(CR+PR)为78.2%,总有效率(CR+PR+SD)为100%。病理显著反应(Ⅱ+Ⅲ)率为73.9%。围手术期并发症与非化疗直接手术者无差别(P>0.05)。化疗的毒性反应中骨髓Ⅲ~Ⅳ度抑制和消化道Ⅲ~Ⅳ度反应均明显低于国外B IP方案(P=0.000,P=0.030)。化疗前后PCNA、K i-67的表达和AI的检测值分别为:0.386±0.078、0.550±0.127...Objective: To determine the Neoadjuvant Chemotherapy(NAC) of cisplatin combined with hydroxycamptothecine、bleomycin regimen(HPB) in Squamous Carcinoma of Uterine Cervix was effective.Methods:107 patients with squamous carcinoma of the uterine cervix,stage Ⅰb～Ⅱb,were treated with one or two cycles of HPB,response and toxicity were observed to evaluate the effect and security of NAC in the treatment of them.The expression of PCNA、Ki-67、CD44v6 and apoptosis index(AI) were detected before and after NAC,with flo...

关 键 词：顺铂 羟基喜树碱 博莱霉素 新辅助化疗 宫颈鳞癌 

分 类 号：R737.33[医药卫生—肿瘤]