基质金属蛋白酶与肿瘤坏死因子α的检测对化脓性脑膜炎与病毒性脑炎的鉴别意义  

Meanings of Detecting Matrix Metalloproteinases and Tumor Necrosis Factor-α for antidiastole between acute Purulent Meningitis and Viral Encephalitis in Children

作　　者：王秀霞[1] 于风雪[1] 刘俊英[1] 郭卓平[1] 

机构地区：[1]河北医科大学第二医院儿科,石家庄050000

出　　处：《脑与神经疾病杂志》2008年第3期206-207,180,共3页Journal of Brain and Nervous Diseases

摘　　要：目的:探讨脑脊液中基质金属蛋白酶(MMP-2、MMP-9)与肿瘤坏死因子α(TNF-α)的检测在化脓性脑膜炎(化脑)与病毒性脑炎(病脑)患儿早期鉴别诊断中的价值。方法:于入院后48小时(病程5天)内采集脑脊液,TNF-α的测定采用放射免疫法,MMP-2、MMP-9的测定采用双抗体夹心ELISA法。结果:化脑组患儿脑脊液中MMP-2、MMP-9与TNF-α的水平明显高于病脑组与对照组。结论:脑脊液中MMP-2、MMP-9与TNF-α水平的检测可作为化脑和病脑患儿早期鉴别诊断的方法之一。Objective:To obtain early antidiastole of acute purulent meningitis(PM)from viral encephalitis(VE)in children through determination of Matrix Metalloproteinases(MMP-2,MMP-9)and Tumor Necrosis Factor-α(TNF-α)level in cerebrospinal fluid(CSF).Methods:The levels of TNF-α in CSF were determined by Radio-immunity,the levels of MMP-2 and MMP-9 in CSF were determined by Enzyme Linked Immunosorbent Assay(ELISA)in 48 hours after hospitalization(in 5 days before onset).Results:The levels of TNF-αand MMP-2,MMP-9 in CS...

关 键 词：化脓性脑膜炎 病毒性脑炎 基质金属蛋白酶 肿瘤坏死因子-Α 

分 类 号：R74[医药卫生—神经病学与精神病学]