阿米洛利对大鼠脑缺血再灌注损伤后线粒体SDH的影响  

Effect of amiloride on the activities of mitochondrial succinic dehydrogenase on cerebral ischemia-reperfusion of rats

作　　者：张三妹[1] 李光来[2] 

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第二医院,山西太原030001

出　　处：《临床医药实践》2008年第1期17-19,共3页Proceeding of Clinical Medicine

摘　　要：目的:探讨阿米洛利对实验性脑缺血再灌注损伤的保护作用。方法:采用结扎大鼠双侧颈总动脉制作不完全脑缺血30 min再灌注24 h模型,观察阿米洛利对脑组织线粒体琥珀酸脱氢酶(SDH)活性的影响。结果:阿米洛利可明显增加脑组织增强SDH的活性。结论:阿米洛利对脑缺血再灌注有保护作用,其机制与其提高脑组织线粒体SDH酶活性,稳定线粒体膜,保护线粒体功能有关。Objective:To study the protection of amiloride on experimental cerebral ischemia-reperfusion damages.Methods:Observing the influence of amiloride on the activity of mitochondrial succinic dehydrogenase(SDH)in brain tissue on the acute experimental incomplete cerebral ischemia model induced by ligating bilateral common carotid arteries for 30 minutes and then reperfusion 24 hours.Results:Amiloride can obviously enhance the activity of SDH.Conclusion:Amiloride possesses stronger protection which has relation ...

关 键 词：阿米洛利 脑缺血再灌注 琥珀酸脱氢酶 

分 类 号：R743[医药卫生—神经病学与精神病学]