肝硬化门静脉高压症猪动物模型的制作  

The establishment of cirrhotic portal hypertension model in pigs

作　　者：贺细菊[1] 李文春[1] 张兴华[1] 黄铁柱[1] 

机构地区：[1]郧阳医学院人体解剖学教研室,十堰442000

出　　处：《陕西医学杂志》2008年第7期792-793,共2页Shaanxi Medical Journal

基　　金：湖北省教育厅科学技术研究项目(D200524002)

摘　　要：目的:探讨用CCl4制作猪肝硬化门静脉高压症模型的方法。方法:采用健康2月龄湖北白猪14头,随机分为两组,其中4头作对照组,10头作实验组。结果:实验组门静脉压力为4.17±1.03kPa,对照组为1.51±0.79kPa,实验组肝假小叶形成,可见腹水和胃底静脉曲张,脾明显增大,ALT、AST明显升高,A/G降低。结论:用CCl4制作肝硬化门静脉高压症猪动物模型的方法是成功可行的。可为门静脉高压状态下研究肝内外血管的生物力学特性提供实验材料。Objective :To explore the methods of establishing the swine model of portal hypertension in hepatic cirrhosis by using carbon tetrachloride.Methods:14 Hubei white pigs aged 2 months were randomly divided into two groups,10 pigs serve as the experimental group,4 pigs serve as the control group.Results:The portal vein pressure of experimental group was 4.17±1.03kPa,that of control group was 1.51±0.79kPa,the sham lobule and ascites forming,the spleen s length and thickness increased significantly,the ALT,AST o...

关 键 词：肝硬化/并发症 门静脉压 模型 动物 猪 

分 类 号：R575.2[医药卫生—消化系统]