祛除白附子麻辣刺激性新技术——超微粉碎  

A New Technique of Superfine Comminution to Dispel Rhizoma Typhon's Sting Eeffects

作　　者：李先端[1] 程立平[1] 仝燕[1] 顾雪竹[1] 游修琪[1] 毛淑杰[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2008年第9期26-29,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局科学技术研究专项(04-05ZL25)

摘　　要：目的:确定祛除白附子麻辣刺激性新技术方法的可行性。方法:采用研磨式超微粉碎法;以中位粒径达11.85μm,最大粒径64μm,90%的粒度在28μm以下为质量控制标准;采用小鼠急性毒性、兔眼结膜刺激、镇静等动物实验,比较了白附子生品、老工艺炮制品、新技术炮制品的药理作用。结果:白附子经超微粉碎后,其毒性、刺激性由强到弱为白附子生品>老工艺炮制品>新技术制品,药效作用与生品、老工艺制品基本一致。结论:白附子经超微粉碎后,可基本祛除白附子麻辣刺激性,同时保持其原有的药效。Objective:To determin the feasibility of the new technique to dispel Rhizoma Typhon s sting and hot irritation.Method:By the ultramicro-pulverzing technique different diameter of ultro-powder particles were used for the compared studies through pharmacologic experiments such as mouse acute toxicity test,rabbit conjunctiva stimulation and sedation tests,etc between the raw Rhizoma Typhon、the old and the new processed Rhizoma Typhon.Result:After the ultramicro-powder ing Rhizoma Typhon nearly has the same pha...

关 键 词：白附子 超微粉碎 药效作用 麻辣刺激性 

分 类 号：R283.6[医药卫生—中药学]