丙谷双肽在晚期食管贲门癌化疗中应用的随机对照研究  

Randomizedly controlled trial on application of parenteral alanyl-glutamine dipeptide in chemotherapy of advanced patients with esophageal and cardiac carcinoma

作　　者：何义富[1] 陈建[1] 王刚[1] 孙玉蓓[1] 王勇[1] 杜建平[1] 陈曼萍[1] 徐腾云[1] 江丰收[1] 胡长路[1] 季楚舒[1] 胡冰[1] 

机构地区：[1]安徽医科大学附属省立医院肿瘤科

出　　处：《中华肿瘤防治杂志》2008年第12期936-938,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：安徽省自然科学基金(070413256X);安徽省教育厅自然科学研究项目(06023090C)

摘　　要：目的:观察丙谷双肽在晚期食管贲门癌化疗过程中对化疗不良反应、机体功能以及客观疗效的影响。方法:将48例晚期食管贲门癌患者随机分为化疗+丙谷双肽组(研究组,24例)和化疗组(对照组,24例),观察两组的不良反应、体质量改变和客观疗效。结果:研究组和对照组口腔黏膜炎、恶心/呕吐、腹泻以及体质量减轻差异均有统计学意义,P值分别为0.016、0.023、0.033和0.042。而两组客观有效率差异无统计学意义,P=0.551。结论:丙谷双肽可减少晚期食管贲门化疗所致的口腔黏膜炎、恶心/呕吐及腹泻发生率,并能改善患者的机体功能,同时不降低化疗疗效。OBJECTIVE:To evaluate the influence of alanyl-glutamine(Ala-Gln) dipeptide on chemotherapy-induced side effect,patient s performance status and objective response rate in the chemotherapy of advanced esophageal and cardiac carcinoma.METHODS: Forty-eight patients with advanced esophageal and cardiac carcinoma receiving primary chemotherapy were randomized into study group(24 cases,20 g Ala-Gln dipeptide in 500 mL compound amino acid injection) and control group(24 cases,500 mL compound amino acid injection)....

关 键 词：食管肿瘤/药物疗法 胃肿瘤/药物疗法 贲门 丙氨酰谷氨酰胺双肽 

分 类 号：R735[医药卫生—肿瘤]