新辅助化疗联合同期放化疗治疗中青年局部晚期鼻咽癌的临床观察  

Effect of neoadjuvant chemotherapy combined with concurrent radiotherapy and chemotherapy for advanced nasopha ryngeal carcinoma in early-to-middle adulthood

作　　者：凌华海[1] 陈焕伟[1] 林文[1] 

机构地区：[1]广东省农垦中心医院肿瘤内科三区,广东湛江524002

出　　处：《中华肿瘤防治杂志》2008年第12期921-923,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:研究新辅助化疗联合同期放化疗治疗中青年局部晚期鼻咽癌的疗效及毒副反应。方法:60例中青年局部晚期鼻咽癌患者随机分为观察组(30例)和对照组(30例)。观察组:PFL方案化疗2个疗程;化疗后1周常规放射治疗同期DDP化疗。对照组单纯放疗。结果:观察组完成治疗后鼻咽部肿瘤完全消退96.7%,对照组90.0%,两组比较差异无统计学意义,χ2=0.27,P>0.05。观察组颈淋巴结转移灶治疗量完全消退90.4%,对照组50.0%。2年内局部复发及远处转移两组分别为20.0%和50.0%。2年无病生存率两组分别为80.0%和50.0%。观察组颈淋巴结转移灶治疗量完全消退情况、2年内局部复发及远处转移情况及2年无病生存率均优于对照组,两组比较差异有统计学意义,P均<0.05。观察组胃肠道反应和骨髓抑制均较对照组明显,但对于中青年患者可耐受。结论:新辅助化疗联合同期放化疗治疗中青年局部晚期鼻咽癌与单纯放疗相比有一定治疗优势,值得在临床上进一步推广。OBJECTIVE: To evaluate the effect and toxicity of neoadjuvant chemotherapy combined with concurrent radiotherapy and chemotherapy on treating stage Ⅲ and ⅣA nasopha ryngeal carcinoma(NPC) in early-to-middle adulthood.METHODS: Sixty early-to-middle adulthood patients of NPC in stage Ⅲ and ⅣA were randomly assigned into two groups.One group were treated by neoadjuvant chemotherapy before concurrent radiotherapy with PFL regimenfor two courses of treatment and followed by routine radiotherapy concomitant chemo...

关 键 词：鼻肿瘤/药物疗法 鼻咽肿瘤/放射疗法 综合疗法 

分 类 号：R739.63[医药卫生—肿瘤]