球囊损伤加高脂喂养建立大鼠髂动脉粥样硬化模型  

Establishing an Iliac Atherosclerosis Model of Rats with Balloon Injury and High-Cholesterol Diet

作　　者：钟武[1] 关霞[1] 龙汉安[1] 杨辉[1] 李国英[1] 施森[1] 周翔宇[1] 

机构地区：[1]泸州医学院附属医院血管外科,四川泸州646000

出　　处：《中外医疗》2008年第21期4-5,共2页China & Foreign Medical Treatment

摘　　要：目的探索建立髂动脉粥样硬化动物模型的有效方法。方法将Wistar大鼠18只,雌雄各半,随机分为三组:高脂(加VD3)+球囊损伤组、高脂组、正常喂养组。在实验第90天检测血清总胆固醇、甘油三酯,分别处死各组动物,并分离各组髂动脉,置于10%中性福尔马林中固定,作HE染色。结果模型组TC、TG水平均明显升高(P<0.05),髂动脉管壁明显增厚,中膜平滑肌细胞增生,管腔内有较典型的动脉粥样斑块。结论球囊损伤及高脂喂养+VD3可成功建立大鼠动脉粥样硬化模型。Objective To establish an effective method of setting up an animal iliac atherosclerosis model. Methods Eighteen Wistar rats,half male and half female,were divided randomly into three groups equally:high-cholesterol dieted and balloon injured group,high-cholesterol dieted group and normal dieted group. TC and TG in serum were detected 90 days from the start. Then the rats were killed separately and their iliac arteries were isolated and fixed in 10% formalin for HE staining. Results In the experimental grou...

关 键 词：动脉粥样硬化 髂动脉 球囊损伤 动物模型 

分 类 号：R-332[医药卫生]