腹腔镜下置管灌洗引流对重症急性胰腺炎猪的治疗作用  

Therapeutic effect of laparoscopic peritoneal lavage and drainage on severe acute pancreatitis in pig

作　　者：鲍世韵[1] 郭跃华[1] 郭长春[2] 张悦[1] 田恒宇[1] 余小舫[1] 

机构地区：[1]暨南大学第二临床医学院(深圳市人民医院)肝胆胰外科,广东深圳518020 [2]暨南大学第二临床医学院(深圳市人民医院)麻醉科,广东深圳518020

出　　处：《中国内镜杂志》2008年第6期564-567,共4页China Journal of Endoscopy

基　　金：深圳市科技计划项目;项目编号:200304009

摘　　要：目的探讨腹腔镜下腹腔置管灌洗引流对重症急性胰腺炎猪的治疗作用。方法采用腹腔镜下主胰管内加压注射牛磺胆酸钠和胰蛋白酶的方法制作猪重症急性胰腺炎模型。将模型动物随机分为两组,每组5只:对照组造模后仅行基础支持治疗,治疗组造模后行腹腔镜下胰周置管灌洗引流和基础支持治疗。于造模前和造模成功后6、24、48和72h测定血清淀粉酶及血浆TNF-!和IL-6的含量,同时观察模型动物的生命体征和存活情况。结果72h内对照组1只家猪死亡,死亡率20%,治疗组无死亡。对照组造模后血清淀粉酶及血浆TNF-"和IL-6的含量明显升高,血清淀粉酶24h时达到高峰为(4901.3±512.4)u/L,6h时血浆TNF-а达到高峰为(1476.7±206.2)ng/L,24h时血浆IL-6达到高峰为(542.5±112.5)ng/L。治疗组造模后各时间点血清淀粉酶及TNF-а和IL-6的含量均显著性低于对照组(P<0.05)。结论腹腔镜下腹腔置管引流能够有效减轻重症急性胰腺炎家猪过度的炎症反应,降低死亡率,改善预后。[Objective] To investigate the therapeutic effect of laparoscopic peritoneal lavage and drainage on severe acute pancreatitis in pig. [Methods] Severe acute pancreatitis models were induced by retrograde injection of 1 mL/kg normal saline containing 5% sodium taurocholate and 4 000 u/mL trypsin through the common pancreatic duct. Ten pigs with severe acute pancreatitis were randomly equally divided into two groups: therapeutic group and control group. The pigs in both group received basic supportive treatme...

关 键 词：重症急性胰腺炎 腹腔镜 置管引流 猪 

分 类 号：R576[医药卫生—消化系统]