端粒酶在萎缩性胃炎大鼠胃黏膜组织中的表达及胃乐益对其影响  

Expression of Telomerase in Gastric Mucosa Tissue and Effects of Weileyi Against Gastric Mucosal Injury in Rats with Chronic Atrophic Gastritis

作　　者：杨胜兰[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,武汉430022

出　　处：《中国中西医结合杂志》2005年第S1期46-48,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察胃乐益对萎缩性胃炎大鼠胃黏膜组织中端粒酶活性的抑制作用。方法将80只大鼠随机分为4组,即正常对照组、模型组、胃乐益治疗组(胃乐益组)、生理盐水对照组(生理盐水组),观察各组胃黏膜组织病理学改变,并应用端粒重复扩增法测定各组胃黏膜组织中端粒酶的活性。结果正常对照组胃粘膜未呈现端粒酶活性,模型组、胃乐益组、生理盐水组端粒酶阳性率分别为60%、25%、55%,胃乐益组与模型组、生理盐水组比较差异均有显著性(P＜0．01)。结论胃乐益对端粒酶的激活有一定的抑制作用,胃乐益治疗慢性萎缩性胃炎作用机制之一可能与其一定程度抑制端粒酶活性有关。Objective To investigate the inhibitory effects of Weileyi(WLY)on telomerase activity in gas- tric mucosal tissue of rats with chronic atrophic gastritis(CAG).Methods Eighty rats were randomly divided into four groups,the normal control group(NCG),the model group(MG),the WLY treated group(WLYG)and the nor- mal saline control group(NSCG),with twenty rats in each group.The pathologic changes were observed,and the telomerase activity in gastric mucose tissue was measured with PCR-based T RARP assay before and ...

关 键 词：端粒末端转移酶 胃肿瘤 基因扩增 胃乐益 

分 类 号：R573.3[医药卫生—消化系统]