关于阻断共刺激通路诱导移植免疫耐受的实验动物研究进展  

Development of laboratory animal research of inducing transplantation immunity tolerance by blockading the costimulatory signal pathways

作　　者：王颖[1] 邓宇斌[1] 

机构地区：[1]中山大学中山医学院病理生理教研室,广东广州510080

出　　处：《免疫学杂志》2004年第z1期69-72,共4页Immunological Journal

基　　金：广东省自然科学基金(A101689);省科技计划(200205050104)资助项目

摘　　要：应用能够使T细胞活化的协同刺激分子的相应单克隆抗体或重组基因表达产物阻断某些共刺激信号通路如CD28/B7、CD154/CD40、LFA-1/ICAM、ICOS/ICOSL等可以抑制T细胞活化、分化以及产生效应细胞。这些共刺激信号通路彼此独立但又可能存在潜在的协同效应。本文综述在有关诱导受体对供体移植物特异性的免疫耐受以此延长移植物存活时间的实验动物研究,以期深入探讨免疫耐受机制以及某些处理因素对结果的影响,从而为此类实验的进一步开展甚至临床应用提供理论依据和实验支持。The corresponding monoclonal antibody or products of recombination gene, which can activate T cells, and can be used to blockade some costimulatory signal pathways that include CD28/B7, CD154/CD40, LFA-1/ICAM, ICOS/ICOSL and so on. Then T cells will be inhibited from activation, differentiation, and yielding effector cells. These costimulatory signal pathways are independent from each other, and probably there is potential synergistic effect among them. In order to investigate the immunological tolerance mechanisms and the influence of different treatments, and to provide theories and experimental help for this kind of experiment even clinical application, this article summarize the laboratory animal research of inducing the specific immunologic tolerance and prolonging survival time of the grafts.

关 键 词：共刺激通路 免疫耐受 复合组织移植 CTLA4 Ig ICOS LFA-1 CD40 

分 类 号：R392.4[医药卫生—免疫学]