BELLINI试验通过探索短期联合免疫检查点抑制(immune checkpoint inhibition,ICI)是否能够诱导免疫激活。在机会窗口期A组[4周抗程序性死亡蛋白1(programmed cell death protein 1,PD-1)治疗]和B组[4周抗PD-1+抗细胞毒T淋巴细胞相关蛋白...
supported by the National Natural Science Foundation of China(82230004,81970113,82300149);the National Key Research and Development Program of China(2021YFC2500304);Capital Health Research and Development of Special(2022-1-4082);Peking University Medicine Fund for world's leading discipline or discipline cluster development(71003Y3035).
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell le...
BACKGROUND Cytotoxic T Lymphocyte Antigen-4(CTLA4)deficiency is a genetic defect that causes a common variable immunodeficiency(CVID)clinical phenotype.Several studies have reported an association between CTLA mutatio...
NHMRC grants APP1113577(MCC,CGV)and APP1079648(MCC,CGV);grant APP1130330 awarded through the Priority-drive Collaborative Cancer Research Scheme and funded by Cancer Australia(MCC,DY,SY).
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency(PAD),analysis of affected patients could yield insights into T-cell differentiation and explain how environm...