supported by National Natural Science Foundation of China(No.82372888);National Key Research and Development Program of China(No.2022YFC2704000);National Natural Science Foundation of China(No.82273383);the Capital’s Funds for Health Improvement and Research(No.2020-2-4098);Youth program of Beijing Municipal Natural Science Foundation(No.7204328);Clinical Medicine Plus X-Young Scholars Project,Peking University(No.PKU2022LCXQ020);Key Clinical Project of Peking University Third Hospital(No.BYSY2022050);Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2021006);Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2019034).
Objective:The expression of programmed death 1(PD-1)on CD8^(+)T cells is associated with their activation and exhaustion,while CD57 serves as a senescence marker.The impact of PD-1^(+)and CD57^(+)CD8^(+)T cells on the...
NHMRC grants APP1113577(MCC,CGV)and APP1079648(MCC,CGV);grant APP1130330 awarded through the Priority-drive Collaborative Cancer Research Scheme and funded by Cancer Australia(MCC,DY,SY).
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency(PAD),analysis of affected patients could yield insights into T-cell differentiation and explain how environm...