中小剂量环磷酰胺间隙疗法治疗重症肌无力  

Interval low or median dose cyclophosphamide for treatment of myasthenia gravis

作　　者：蒋建明[1] 涂来慧[1] 吴涛[1] 张仁琴[1] 丁素菊[1] 

机构地区：[1]第二军医大学长海医院神经内科,上海200433

出　　处：《第二军医大学学报》2004年第12期1368-1370,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30270486)

摘　　要：目的:观察中小剂量环磷酰胺间隙疗法治疗重症肌无力的疗效和不良反应.方法:选择综合治疗效果不佳的ⅡB型或Ⅳ型难治性重症肌无力患者15例,给予环磷酰胺0.2 g/d静脉滴注,6 d为1个疗程,间隔1～3个月重复1次,共3～6个疗程,随访0.5～3年.结果:15例患者治疗1个月后症状开始改善,治疗3个月后疗效评价:显效8例,有效7例.随访0.5～3年,不良反应少而轻微,仅少数患者用药时出现恶心,用药后短期脱发,均不需特殊处理.结论:中小剂量环磷酰胺间隙疗法治疗重症肌无力疗效可靠,无严重不良反应,值得进一步观察试用.Objective:To assess the efficacy and side effects of interval low or median dose cyclophosphamide for treatment of myasthenia gravis. Methods: Fifteen patients with myasthenia gravis Ⅱ B or Ⅳ type, which could not be controlled well by usual comprehensive treatment, were given low or median dose cyclophosphamide(200 mg intravenously per day) for 6 consecutive days. The treatments were repeated 3-6 times after every 1-3 months. The patients were followed up for 0. 5-3 years. Results: All the 15 patients were improved 1 month later, with 8 obvious remissions and 7 improvements after 3 months. The side effects were rare and slight. Only a few patients had nausea during treatment and slight diarrhea several days after being treated. All the side effects need no special treatment. Conclusion : This interval low or median dose cyclophosphamide treatment appears to be an effective and safe treatment for the refractory myasthenia gravis. Further followup and more patients study is needed to determine the long-term outcome.

关 键 词：重症肌无力 环磷酰胺 治疗学 

分 类 号：R746.1[医药卫生—神经病学与精神病学]