5-ALA诱导荧光膀胱镜下膀胱肿瘤电切除术(附31例报告)  

Transurethral resection of bladder cancer using 5-aminolevulinic acid induced fluorescence endoscopy(Report of 31 cases)

作　　者：宋晓东[1] 叶章群[1] 周四维[1] 杨为民[1] 刘继红[1] 庄乾元[1] 张旭[1] 马扬之[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,武汉430030

出　　处：《临床泌尿外科杂志》2003年第11期665-667,共3页Journal of Clinical Urology

基　　金：国家自然科学基金资助 (NO .30 2 71 30 0 )

摘　　要：目的 :探讨 5 ALA诱导荧光膀胱镜下膀胱肿瘤电切治疗的彻底性。方法 :对 31例血尿患者在 5 ALA诱导荧光染色膀胱镜下行活组织检查及电切术。结果 :31例呈荧光阳性 ,其中 2 6例经术后病理证实为尿路上皮癌 ,5例为良性病变。其中 1 1例移行细胞癌患者在癌旁或远处发现普通膀胱镜下无法识别的微小荧光阳性区域 ,经活检均证实有肿瘤存在。对该区域均在荧光指示下进行电切或电灼术。结论 :5 ALA诱导荧光膀胱镜检对膀胱肿瘤诊断高度敏感 ,能发现微小及癌旁肿瘤 ,在荧光指示下能彻底切除肿瘤 。Purpose:To evaluate the efficacy of transurethral resection of bladder tumor (TURBt) using 5 ALA induced fluorescence endoscopy.Methods:31 cases of hematuria were examied by 5 ALA induced fluorescence endoscopy and followed by biopsy and TURBt treatment.Results:31 cases were found to have fluorescence positve bladder wall.On histopathologic studies, 26 of them were found to have urothelial cell carcinoma and 5 cases benign lesions. In 11 of all patients with transitional cell carcinoma, small flat fluorescence positve lesions nearby tumor or in other region were found to be transitional cell carcinoma, which could not detected by white light cystoscopy. All these region were resected by TURBt or electrofulguration.Conclusions:5 ALA induced fluorescence endoscopy was a highly sensitve procedure for detecting bladder cancer.It could detect small tumor lesions and should be helpful to the radical resection of bladder tumor and reduction of tumor recurrence.

关 键 词：膀胱肿瘤 荧光膀胱镜 经尿道电切除术 5-氨基乙酰丙酸 

分 类 号：R737.14[医药卫生—肿瘤]