博尔纳病病毒感染的免疫发病机制  

Immunopathogenesis of Borna disease virus infection

作　　者：徐平[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016

出　　处：《免疫学杂志》2003年第S1期87-90,共4页Immunological Journal

基　　金：国家自然科学基金(39870252)

摘　　要：博尔纳病病毒(BDV)是单股负链RNA病毒,在体内和体外都缺乏细胞致病性。BDV可引起中枢神经系统持续感染并导致博尔纳病(BD),即免疫介导的脑脊髓炎。浸润的免疫细胞以CD4^+T细胞、CD8^+T细胞、巨噬细胞和B细胞为特征。CD8^+T细胞代表对核蛋白呈抗原特异性的效应细胞群。The single-stranded RNA Borna disease virus (BDV) , lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infection of the central nervous system and induces Borna disease (BD), an immune-mediated encephalo-myelitis. The infiltrating immune cells have been characterized as CD4-positive, CDS-positive T-cells, macrophages and B cells. CD8-positive T cells represent the effector cell population exhibiting antigen specificity for the nucleoprotein.

关 键 词：博尔纳病病毒 免疫学 发病机制 

分 类 号：R363[医药卫生—病理学]