p53、bcl-2基因和雌孕激素受体在乳腺癌表达的临床意义  

Clinical significance of expressions of p53 gene, bcl-2 gene, estrogen receptor and progestagen receptor in breast cancer

作　　者：韩晶[1] 金宗浩[1] 党云文[1] 

机构地区：[1]同济大学附属同济医院乳腺外科,上海200065

出　　处：《上海医学》2003年第S1期13-15,共3页Shanghai Medical Journal

摘　　要：目的　探讨 p5 3基因、bcl 2基因、雌激素受体 (ER)及孕激素受体 (PR)在乳腺癌中表达的意义及其相互之间的关系。方法　采用免疫组化SP法检测 116例乳腺癌患者的p5 3、bcl 2、ER及PR。结果　癌组织中p5 3、bcl 2、ER及PR阳性反应检出率分别为 2 2 .4%、48.3 %、73 .3 %和 5 6.9% ;有淋巴结转移的乳腺癌患者p5 3基因表达明显高于无淋巴结转移者 ,ER的表达与p5 3相反。bcl 2基因在病理TNM分期早期乳腺癌中的表达明显高于中、晚期乳腺癌。PR的阳性率表达与患者的年龄、肿块直径、淋巴结转移及TNM分期均呈负相关(P <0 .0 5 )。结论　p5 3、bcl 2、ER和PR均可作为判断乳腺癌预后的指标。p5 3和bcl 2的表达呈负相关 ,bcl 2和ER、PR呈正相关 ,且有协同性。bcl 2阳性表达还可作为乳腺癌早期诊断的指标。Objective To appraise the significance of the expressions of p53 gene, bcl 2 gene, estrogen receptor (ER) and progestagen receptor (PR) in breast cancer and their interrelations. Methods The expression of p53, bcl 2, ER and PR were studied in 116 breast cancer patients by SP method. Results The positive rates of p53, bcl 2, ER and PR were 22.4%, 48.3%, 73.3% and 56.9% respectively. The expression of p53 in cases with lymph node metastasis were significantly higher than those without expression of ER ...

关 键 词：乳腺肿瘤 癌基因 雌激素受体 孕激素受体 预后 相关性 

分 类 号：R737.9[医药卫生—肿瘤]