人参总皂甙对阿尔茨海默病模型大鼠海马生长抑素神经元的影响  

Effect of Ginsenosides on Somatostatin Neurons in Rats Model of Alzheimer's Disease

作　　者：董静尹[1] 孙百强[1] 

机构地区：[1]浙江大学医学院解剖学教研室,杭州310031

出　　处：《中国中西医结合杂志》2003年第S1期45-47,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助(No.C03050205)

摘　　要：目的:研究人参总皂甙(ginsenoside,GS)对 D-半乳糖合并鹅膏蕈氨酸(ibotenic acid,IBO)所致阿尔茨海默病(Alzheimer's disease,AD)模型大鼠海马生长抑素(somatostatin,SS)神经元的影响。方法:本实验将2月龄 SD 大鼠随机分为正常组、模型组和治疗组。模型组以 D-半乳糖和 IBO 损毁脑内双侧 Meynert核造模;治疗组在造模后腹腔注射 GS。采用免疫组化 ABC 法结合图像分析,检测各组大鼠海马 SS 神经元数目、截面积和灰度值。结果:正常组、治疗组、模型组大鼠海马 SS 神经元数目和灰度值分别呈递减、递增趋势,部分组间差异有显著性(P<0.01);各组阳性神经元截面积差异无显著性(P>0.05)。结论:GS 可减轻 D-半乳糖合并 IBO 所致 AD 模型大鼠海马 SS 神经元的衰退,从形态学上初步证实 GS 对 AD 具有治疗效应。Objective:To study the effects of ginsenoside (GS) on somatostatin (SS) neurons in rats model of Alzheimer s disease (AI)) in duced by D-galactose and ibotenic acid (IBO).Methods:SD rats,two months old,were randomized into the normal group,the model group and the treated group.Rats in the model group were modeled by D-galactose and bilateral basal Meynert nuclei injury with IBO.The treated group was treated intraperitoneally with GS after being modeled.The number of SS neurons of hippocampus, grey value and...

关 键 词：人参总皂甙 阿尔茨海默病 海马 生长抑素 

分 类 号：R285.5[医药卫生—中药学]