p53蛋白和P-gp、TopoⅡ蛋白在食管鳞状细胞癌的表达及意义  

Expression of p53 Protein and P-gp, TopoⅡ Protein in Esophageal Cancer Cell and Clinical Significance

作　　者：张红[1] 林贤东[1] 何诚[1] 陆莉丽 

机构地区：[1]福建省肿瘤医院病理科,福州350004

出　　处：《福建医科大学学报》2003年第S1期67-69,109,共4页Journal of Fujian Medical University

摘　　要：目的　研究食管鳞状细胞癌 P- gp、Topo 蛋白与抑癌基因 p5 3的表达以及与食管癌生物学行为之间的关系。　方法　用免疫组织化学方法对 5 0例食管癌组织标本 P- gp、Topo 蛋白及 p5 3表达进行检测。　结果　食管癌组织中 p5 3阳性率为 6 4 % ,P- gp阳性率为 4 2 % ,p5 3阳性组的 P- gp表达率 (5 3.1% )显著高于阴性组(2 2 .2 % ,P<0 .0 5 ) ,p5 3表达与 P- gp有关。 p5 3与 Topo 蛋白表达之间关系无显著意义。 P- gp、Topo 表达与患者年龄、性别、肿瘤分化程度以及淋巴结转移无关。　结论　 p5 3表达可引起多药耐药 MDR- 1编码产物表达增高 ,从而使食管癌细胞获得多药耐药 MDR- 1表型 ;P- gp虽可作为化疗敏感性的预测 ,但不能作为判断预后的独立指标。Objective\ To study P\|gp and p53 expression in esophageal cancer tissues and its relation to biological factors.\ Methods\ 50 esophageal cancer specimens were examined for p53 protein, P\|gp and TopoⅡ by immunohistochemical methods.\ Results\ The positive rate of p53 expression is 64%, P\|gp is 42%.\ In p53 positive groups the levels of P\|gp expression(53 1%) was significantly higher than(22 2%) p53 negetive groups(P<0 05).\ There was no significant correlation between p53 and TopoⅡ expression.\ The...

关 键 词：食管肿瘤 蛋白质P53 P-糖蛋白类 抗药性 肿瘤 

分 类 号：R735.1[医药卫生—肿瘤]