SDF-1及受体CXCR4在中枢神经系统的作用  

Effects of SDF-1 and CXCR4 on the nervous system

作　　者：范寿成[1] 杨智勇[1] 

机构地区：[1]昆明医学院第一附属医院神经外科,云南昆明650032

出　　处：《河南外科学杂志》2008年第6期78-79,共2页Henan Journal of Surgery

摘　　要：趋化因子是具有趋化作用的一类细胞因子,参与白细胞迁移的调控,在炎症中诱导性表达,与炎症过程密切相关,最初的研究主要局限于免疫系统。近几年来研究发现,趋化因子不仅参与神经系统疾病的炎症过程,而且在神经细胞成熟、发育、血管生成、肿瘤、艾滋病等发挥重要作用。本文主要针对趋化因子SDF-1及受体CXCR4在神经系统中的作用及相关机制的研究成果予以综述,将有助于深入理解趋化因子与神经系统的关系,为进一步的研究提供依据。Chemokines,a variety of chemotactic cytokines,play a pivotal part in the control of leukocytetrafficking.Because chemokines and their receptors were intimately involved in the orchestration of inflammatoryresponses and inducibly expressed,the initial researches were confined to the immune system.However,recent intriguing findings revealed that it also have an important effect on nerve cellular maturation and development,angiogenesis,astrocytoma,AIDS.This review article summarizes the recent advances in the ...

关 键 词：SDF-1 CXCR4 中枢神经系统 

分 类 号：R741[医药卫生—神经病学与精神病学]