缺血性脑血管病患者趋化因子受体CX3CR1基因T280M多态性的研究  

Study on chemokine receptor CX3CR1 gene T280M polymorphism in patients with ischemic cerebrovascular disease

作　　者：彭旭[1] 张智博[1] 唐璐[1] 周颖[1] 

机构地区：[1]南华大学长沙市第一医院神经内科,410005

出　　处：《临床神经病学杂志》2008年第5期329-332,共4页Journal of Clinical Neurology

基　　金：长沙市科学技术局科技计划项目(K06070027-32)

摘　　要：目的探讨缺血性脑血管病(ICVD)患者趋化因子受体CX3CR1基因T280M的多态性及其频率。方法采用聚合酶链反应和限制性片段长度多态性方法检测165例ICVD患者(脑梗死85例,腔隙性脑梗死40例,短暂性脑缺血发作40例)与150名健康对照者(正常对照组)CX3CR1基因T280M的多态性,比较两组及ICVD亚组的基因频率。结果正常对照组CX3CR1基因T280M只有TT和TM基因型,ICVD组有TT、TM和MM3种基因型,两组间基因型的差异有统计学意义(P<0.05);ICVD组M等位基因频率(8.7%)明显高于正常对照组(2.3%)(P<0.01);不同ICVD亚组之间基因型及M等位基因频率的差异无统计学意义(均P>0.05)。结论ICVD患者趋化因子受体CX3CR1基因T280M有MM基因型,并且M等位基因的频率明显增高,提示CX3CR1基因T280M多态性可能与ICVD有关。Objective To investigate chemokine receptor CX3CR1 gene T280M polymorphism in patients with ischemic cerebrovascular disease(ICVD) and its frequency.Methods 165 patients with ICVD(cerebral infarction 85 cases,lacunar infarction 40 cases,transient ischemic attack 40 cases) and 150 age- and sex-matched healthy controls(normal control group) were involved in this study.The polymorphism of T280M was analyzed by multiplex polymerase chain reaction-restriction fragment length based(PCR-RFLB),the gene frequency wa...

关 键 词：趋化因子 受体 CX3CR1 缺血性脑血管病 

分 类 号：R743.3[医药卫生—神经病学与精神病学]