近红外光谱技术在帕金森病大鼠脑组织射频毁损术中的应用  

Application of near-infrared spectroscopy technology in studying the damage of rats with Parkinson disease by radiofrequency

作　　者：吴琦[1] 杨天明[1] 钱志余[2] 毛雯岚[2] 郭丽娜[2] 何亮[1] 

机构地区：[1]东南大学附属中大医院神经外科,江苏南京210009 [2]南京航空航天大学生物医学工程系,江苏南京210016

出　　处：《现代医学》2008年第4期225-229,共5页Modern Medical Journal

基　　金：国家自然科学基金资助项目(30671997)

摘　　要：目的探索近红外光谱(NIRS)技术用于立体定向靶点毁损术中实时监测的可行性,并观察此过程中NIRS参数的变化规律。方法在大鼠脑纹状体采用两点注入法注入6-OHDA建立帕金森病(PD)大鼠模型;对正常及PD大鼠进行射频毁损,观察并记录脑组织靶点毁损时的NIRS尤其是优化散射系数的变化情况。结果(1)50只大鼠中有40只经阿扑吗啡(APO)诱导后表现为恒定左侧旋转,旋转圈数超过7 r.min-1。(2)射频毁损丘脑腹外侧核(Vim)时,在各温度点下NIRS出现特征性变化曲线。结论利用NIRS实时活体在位监测帕金森大鼠射频神经核团毁损术是科学、可行的,优化散射系数是监测的良好指标。Objective To explore the feasibility of using near-infrared spectroscopy(NIRS) technology to monitor real-time target in the stereotactic destruction technology and to observe the process of changes in the parameters.Methods The establishment of animal models: inject 6-hydroxydopamine(6-OHDA) into the striatum at two points to establish the rat model of Parkinson disease(PD).Target destruction in near infrared spectroscopy monitoring:reversible radiofrequency ablation was implemented on normal and PD rats.C...

关 键 词：近红外光谱技术 优化散射系数 立体定位技术 帕金森病 神经核团毁损术 大鼠 

分 类 号：R742.5[医药卫生—神经病学与精神病学]