磷酸二酯酶4D基因多态性与缺血性脑血管病的关系  

Relationship between phosphodiesterase 4D gene polymorphism and ischemic cerebral vascular disease

作　　者：徐淑兰[1] 张颖冬[1] 林兴建[1] 

机构地区：[1]南京医科大学附属脑科医院神经内科,210029

出　　处：《临床神经病学杂志》2008年第4期249-252,共4页Journal of Clinical Neurology

摘　　要：目的探讨中国汉族人群磷酸二酯酶4D(PDE4D)基因多态性与缺血性脑血管病(ICVD)的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测116例ICVD患者和110名正常对照者PDE4D基因SNP45、SNP83和rs918592位点的多态性及其与糖代谢指标的关系。结果PDE4D基因rs918592的A等位基因频率ICVD组(58.6%)、腔隙性脑梗死亚组(63.8%)较正常对照组(48.6%)明显增高(均P<0.05);rs918592、SNP83基因型及等位基因频率各组间差异无统计学意义(均P>0.05);SNP45位点未见多态性。糖代谢指标在不同的SNP83、rs918592基因型间差异无统计学意义(均P>0.05)。结论中国汉族人群PDE4D基因rs918592位点上A等位基因可能是ICVD的危险因素之一;PDE4D基因可能不是通过糖代谢影响ICVD的发生。Objective To investigate the relationship between phosphodiesterase 4D (PDE4D) gene polymorphism and ischemic cerebral vascular disease( ICVD) in the Han people in China. Methods The single-nucleotide polymorphism in SNP45,SNP83 and rs918592 of PDE4D gene were determined by PCR-RFLP and the relationship between the them and glycometabolic indeces were analysed in 116 cases( ICVD group) and 110 normal controls (NC group). Results The rate of A-allele in rs918592 was significantly higher in ICVD group (58.6%)...

关 键 词：磷酸二酯酶4D基因 单核苷酸多态性 缺血性脑血管病 

分 类 号：R743.32[医药卫生—神经病学与精神病学]