Study on the Effects of FCu-IUD and FICu-IUD on Matrix metalloproteinases in Human Uterine Flushing and Endometrium  

作　　者：李玮 曹路敏 陈早姣 李万 杜庆玲 陈桂萍 

机构地区：[1]Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 [2]Institute of Women and Children Health of Wuhan Steel and Iron Group, Wuhan 430080

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2002年第1期9-11,16,共4页华中科技大学学报（医学英德文版）

基　　金：This project was supported by a grantfrom Hubei Scienceand Technology Comm ittee (No.96 1P190 1)

摘　　要：The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu IUD (fixed Cu IUD) or FICu IUD (indomethacin releasing FCu IUD) was observed by using zymography on SDS PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu IUD group were increased significantly as compared with themselves before being inserted FCu IUD. However, compared with the FCu IUD group, the activity of some kinds of MMPs in the FICu IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD induced menorrhagia and indomethacin reduces IUD induced menorrhagia by partly inhibiting MMPs synthesis.The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu IUD (fixed Cu IUD) or FICu IUD (indomethacin releasing FCu IUD) was observed by using zymography on SDS PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu IUD group were increased significantly as compared with themselves before being inserted FCu IUD. However, compared with the FCu IUD group, the activity of some kinds of MMPs in the FICu IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD induced menorrhagia and indomethacin reduces IUD induced menorrhagia by partly inhibiting MMPs synthesis.

关 键 词：matrix metalloproteinase IUD uterine flushing ENDOMETRIUM ZYMOGRAPHY 

分 类 号：R363[医药卫生—病理学]