转移抑制基因nm23-H1在胆管细胞癌中的表达  

Expression of Antimetastatic Gene nm23-H1 in Cholangiocarcinomas

作　　者：马文锋[1] 杨栋[1] 翟秀岩 

机构地区：[1]中国医科大学第一临床学院外科,辽宁沈阳110001 [2]中国医科大学基础医学院发育生物学研究室

出　　处：《中国医科大学学报》2002年第z1期11-13,共3页Journal of China Medical University

摘　　要：目的:探讨转移抑制基因nm23-H1的表达与胆管细胞癌临床病理及预后的关系。方法:25例胆管细胞癌标本,制成石蜡切片,采用免疫组织化学ABC法染色。结果:11例（40％）为阳性表达,14例（56％）为阴性表达。nm23-H1的表达与肿瘤大小、肿瘤部位、侵及浆膜、肝外转移、肿瘤破裂、淋巴结转移、侵及门静脉、分化程度和生存率无关。术后2年内的复发率nm23-H1阴性表达例（71.4％）高于阳性表达例（45.5％）,但这一区别没有显著性差异（P>0.05）。结论:nm23-H1在胆管细胞病中所起的作用不同。nm23-H1的表达对胆管细胞癌不具有预后指示作用。Objective: The purpose of this study was to investigate the relationship between the expression of anti-metastatic gene nm23-H1 and clinicopathologic features, prognosis of cholangiocarcinomas. Methods: Twenty-five specimens of cholangiocarcinomas were made into paraffin sections and stained with ABC method of immunohistochemistry. Results: Eleven had positive expression, and 14 had negative expression . Expression of nm23-H1 was not associated with tumor size, tumor location, serosal infiltration, extrahepatic metastasis, tumor rupture, lymph node metastasis, portal involvement, cell differentiation, and survival rate. Recurrence rate within 2 years was 71.4% in negative cases, which was more than that in positive cases(45.5% ). But this difference was not statistically significant P >0.05). nm23-H1 may play various roles in cholangiocarcinomas. Conclusion: The gene expression of nm23-H1l is not considered as a prognostic indicator for cholangiocarcinomas.

关 键 词：NM23-H1 胆管细胞癌 

分 类 号：R730.2[医药卫生—肿瘤]