免疫联合中药胃泰胶囊治疗幽门螺杆菌感染小鼠的实验研究  

Experimental Study on Treatment of Helicobacter Pylori Infection in Mice with Combined Immune Therapy and Weitai Capsule

作　　者：朱萱[1] 李弼民[1] 陈江[1] 谢勇[1] 王崇文[1] 肖小华[1] 黄德强[1] 

机构地区：[1]江西医学院第一附属医院消化科,南昌330006

出　　处：《中国中西医结合杂志》2002年第S1期121-123,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江西省自然科学基金(No.984022)

摘　　要：目的:通过建立人类幽门螺杆菌(helicobacter pylori,HP)BALB/C 小鼠模型,研究免疫联合中药胃泰胶囊在治疗 HP 感染中的作用。方法:通过灌喂途径建立人类 HP BALB/C 小鼠模型,把已感染上 HP 的小鼠分为6组:A 组给予尿素酶加霍乱毒素 B 亚单位(CTB)加羟磷灰石(HAP)、B 组给予尿素酶加 CTB 加HAP 加中药胃泰、C 组给予胃泰、D 组给予尿素酶、E 组给予 CTB 加 HAP,F 组为空白对照组;其中尿素酶每周1次共4周,胃泰胶囊每天1次共2周,治疗结束后4周将小鼠处死,取胃粘膜行尿素酶试验和 Giemsa 染色,检查 HP 感染情况。结果:各组 HP 的根除率分别为:A 组61.5%、B 组75.0%、C 组53.8%,D、E、F 组均为0:A、B、C 组小鼠胃粘膜的炎症明显减轻。结论:尿素酶联合中药胃泰胶囊对幽门螺杆菌感染有较好的清除作用,并能较好减轻胃粘膜炎症。Objective:To study the effect of combined immune therapy and Weitai Capsule(WTC)in treating Helicobacter pylori(HP)in- fection.Methods:Human HP infected model was established by HP feeding to BALB/C mice.The infected mice were divided into 6 groups,and treated with:A:urase+cholera toxin B(CTB)+hydroxylapatite(HAP);B:urase+CTB+HAP+WTC;C:WTC;D: urase;E:CTB+HAP and F:untreated.Urase was given once a week for 4 weeks and WTC was given once a day for 2 weeks.Mice were sacrificed 4 weeks after treatment,and their...

关 键 词：幽门螺杆菌 尿素酶 中药 免疫 治疗 

分 类 号：R573[医药卫生—消化系统]