恶性肿瘤血清TNF-α测定的临床意义  

Tumor Necrosis Factor-α in Serum From Tumor Patients

作　　者：高中度[1] 茅爱武[1] 范红[1] 邱崇伦 陈健[3] 

机构地区：[1]上海市同仁医院,上海200050 [2]上海市华阳生物制剂研究所 [3]解放军第455医院

出　　处：《中国医师杂志》2002年第S1期46-47,共6页Journal of Chinese Physician

摘　　要：目的　观察肿瘤患者血清TNF α的变化及临床意义。方法　应用放射免疫测定法对 2 0例健康对照者和 70例肿瘤患者进行了血清TNF α含量测定。结果　对照组血清TNF α的含量较低 ,肿瘤患者明显升高(P <0 0 1) ;肿瘤转移和 /或复发时无进一步上升 ,而肿瘤合并胸腹水和恶液质时TNF α上升明显。结论　肿瘤患者血清TNF α水平明显高于对照组 ,随着肿瘤的局部控制及消退 ,体内TNF α含量呈下降趋势 ,因此TNF α含量的变化对肿瘤患者病情变化及预后的判定 。Objective To detect the changes of tumor necrosis factor α in tumor patients.Methods The content of TNF α in serum was determined by radioimmunoassay (RIA) in 20 controls,70 patients with malignant tumor.Results The content of TNF α in serum in control group was lower significantly than that of tumor group(P<0 01).The level of TNF α in cancer patients decreased after operation or radiotherayp.They did not show further increasing of the content of TNF α in recurrent or/and metastatic patients.W...

关 键 词：肿瘤坏死因子Α 预后 

分 类 号：R730.43[医药卫生—肿瘤]