巨噬细胞移动抑制因子和p^(53)及MVD在食道鳞癌组织中的表达与意义  

Significance of Expression of MIF、p^(53) and MVD in Esophageal Squamous Cell Carcinoma

作　　者：陈亮[1] 扎西[1] 于志敏[1] 

机构地区：[1]青海大学附属医院,青海西宁810001

出　　处：《实用医技杂志》2008年第25期3320-3321,共2页Journal of Practical Medical Techniques

摘　　要：目的:探讨巨噬细胞移动抑制因子(MIF)、p53和CD34在食管鳞癌组织表达的相关性。方法:应用免疫组织化学技术对63例食管鳞癌(ESCC)组织中的MIF、p53的表达,新生血管热区的CD34阳性微血管密度(MVD)进行研究。结果:食道鳞癌MIF、p53总体阳性表达率及MVD分别为93.8%(60/64)、84.3%(54/64)及(31.12+12.20)/高倍视野,明显高于正常胃黏膜组(P<0.05),伴有淋巴结转移的癌组织中p53及MVD水平均高于无淋巴结转移的癌组织(P<0.05),MIF、p53和MVD在低分化食管鳞癌的表达率分别为:100%、95.2%和(40.13±20.04)/高倍视野,与高分化食管鳞癌组织差别具有显著性(P<0.05);MIF和p53及MVD表达呈正相关(P<0.05)。结论:MIF、p53和MVD在低分化胃癌、淋巴结转移组织中表达明显增高,且两者的表达有呈明显的正相关。提示MIF是与食道癌密切相关的因子之一。Objective To explore the relationship between macrophage migration inhibitory factor、p53 and CD34 in esophageal squamous cell carcinoma(ESCC).Methods MIF、p53 expression and microvessel density(MVD) from 63 cases of ESCC tissue were researched with immunochemistry technology.Results The expression rate of MIF,p53 and MVD in ESCC were 93.8%,84.3% and(31.12+12.20)/HPF,it is obviously higher than normal stomach(P<0.01);The expression rate of MIF,p53 and MVD with poorly differentiated were 100%,95.2% and(40.1...

关 键 词：巨噬细胞移动抑制因子 食管鳞癌 p^(53) CD34 

分 类 号：R735.1[医药卫生—肿瘤]