血管内皮生长因子D在胃癌中的表达及其意义  

Expression and significance of vascular endothelial growth factor D in gastric carcinoma

作　　者：李效良[1] 逄小红[1] 齐冰[1] 李永芳[1] 郭淼[1] 赵静[1] 刘京昇[1] 

机构地区：[1]泰山医学院生物学教研室,山东泰安271016

出　　处：《中国现代医学杂志》2008年第20期2969-2971,2975,共4页China Journal of Modern Medicine

基　　金：山东省自然科学资金资助项目(No:2005ZRB14001)

摘　　要：目的研究胃癌组织中血管内皮生长因子D(vascular endothelial growth factor-D,VEGF-D)的表达情况及其意义。方法采用免疫组化SP法检测76例胃癌组织中VEGF-D的表达情况,同时应用Podoplanin标记淋巴管,检测胃癌组织中的微淋巴管密度(lymphatic microvessel density,LMVD)。结果76例胃癌组织中VEGF-D的阳性表达率为52.6%,癌周正常组织中未见VEGF-D抗原表达。VEGF-D的阳性表达率与肿瘤浸润深度、淋巴结转移及TNM分期有关(P<0.05或P<0.01)。胃癌组织中的LMVD明显高于癌周正常组织(P<0.01),LMVD与VEGF-D表达、肿瘤TNM分期和淋巴结转移有关(P均<0.01)。结论胃癌细胞可分泌VEGF-D,它通过诱导淋巴管生成来促进胃癌经淋巴道转移。VEGF-D和LMVD可作为预测胃癌淋巴转移的重要指标。Objective To investigate the expression and significance of vascular endothelial growth factor D(VEGF-D) in gastric carcinoma.MethodsThe expression of VEGF-D was observed by SP immunohistochemistry in 76 gastric carcinoma samples.Lymphatic microvessel density(LMVD) in gastric carcinoma was calculated by using Podoplanin as the specific marker of lymphatic endothelium.ResultsThe positive rate of VEGF-D in gastric carcinoma was 52.6%, and no expression of VEGF-D was detected in peritumoral normal tissues.The ...

关 键 词：胃肿瘤 血管内皮生长因子 淋巴管密度 

分 类 号：R735.2[医药卫生—肿瘤]