大肠癌组织paxillin mRNA表达及其临床病理意义  

Expression of paxillin mRNA in colorectal carcinoma and its clinicopathological significance

作　　者：杨红军[1] 丁彦青[1] 周军[1] 

机构地区：[1]南方医科大学病理学教研室,广东广州510515

出　　处：《中国现代医学杂志》2008年第20期2931-2934,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:30170423)

摘　　要：目的检测桩蛋白(paxillin) mRNA在大肠癌及癌旁正常组织中的表达,并探讨其在大肠癌发生发展中的临床病理意义。方法采用荧光定量逆转录PCR(FQ-RT-PCR)检测41例大肠癌及癌旁正常组织中paxillin mRNA的表达。结果paxilin mRNA在大肠癌组织中表达较高,而在癌旁正常组织中表达较低(P=0.000);有淋巴结转移者较无转移者paxillin mRNA表达高(P=0.000);癌组织浸润程度越深paxillin mRNA表达越高(P=0.007)。结论paxillin与大肠癌的浸润转移有关,可作为大肠癌发生、发展的预测指标之一。Objective To detect the mRNA expression of paxillin in colorectal carcinoma and adjacent normal tissues and investigate the clinicopathological significance of paxillin in tumorigenesis and progression of colorectal carcinoma.MethodsThe expression of paxillin mRNA in 41 samples of colorectal carcinoma and adjacent normal tissues was examined using fluorescence quantitative RT-PCR(FQ-RT-PCR).ResultsThe paxillin mRNA levels in colorectal carcinoma tissues were significantly higher than those in adjacent norma...

关 键 词：大肠癌 桩蛋白 荧光定量PCR 

分 类 号：R735.34[医药卫生—肿瘤]