抗毒复明滴眼液的急性毒性与眼部刺激试验研究  

Experimental Study on the Acute Toxicity and the Eye Irritating Reaction of Herbal Eye Drop of Kangdufuming

作　　者：林琪玲[1] 李明东[1] 周旌[1] 李映红[1] 陈茵[1] 

机构地区：[1]南方医科大学附属深圳医院,广东深圳518035

出　　处：《深圳中西医结合杂志》2008年第4期212-214,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药管理局建设中医药强省重点课题(1060148)

摘　　要：目的:评估中药科研制剂抗毒复明滴眼液的急性毒性与眼的刺激反应。方法:以最大耐受量法(40mL/kg,共3次)观察抗毒复明滴眼液对对小鼠的不良反应;并与生理盐水对照,观察常规治疗7d对兔眼的刺激情况。结果:抗毒复明滴眼液对兔及小鼠都未发生全身和局部不良反应。结论:抗毒复明滴眼液安全性大,而且无局部刺激性。Objective To evaluate the acute toxicity and the eye irritating reaction of herbal eye drop of Kangdufuming. Methods Using the maximal tolerance dose method to evaluate the acute toxicity in mice; observing the irritating eye reaction by treating the rabbit eyes 7 days. Results No general and local side effects occurred both in rabbits and mice. Conclusion The Kangdufuming eye drop are safety and no irritating reaction.

关 键 词：实验性单纯疱疹性角膜炎 抗毒复明滴眼液 毒理试验 

分 类 号：R772.21[医药卫生—眼科]