尼美舒利颗粒剂的溶出度方法研究  

Study on Dissolution for Nimesulide Granules

作　　者：夏瑞[1] 代红[1] 车宝泉[1] 赵明[1] 

机构地区：[1]北京市药品检验所,北京100035

出　　处：《中国现代应用药学》2008年第z1期654-656,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立尼美舒利颗粒剂溶出度的测定方法。方法采用浆法,以磷酸缓冲液(pH8.0)为溶出介质;溶出量采用高效液相色谱的方法测定。以Diamond C18柱(250 mm×4.6 mm,5μm),流动相为0.1%磷酸溶液-甲醇(45∶55),流速为1mL.min-1,检测波长299 nm。结果在15 min内不同厂家生产的尼美舒利颗粒剂的溶出度均能达到75%。结论方法简单,准确可靠,可用于尼美舒利颗粒剂的溶出度测定。OBJECTIVE A method for the determination of dissolution of Nimesuide Granules in vitro was established.METHODS The Apparatus 2 was used and phosphate buffer(pH 8.0) was used as dissolution medium;HPLC was applied to determine the dissolution of Nimesulide Granules.The analyses were performed on a Diamond C18 column(250 mm×4.6 mm,5 μm)using 0.1% phosphate acid solution-methanol(45∶55) as mobile phase at a flow of 1 mL·min-1.The detection wavelength was 299 nm. RESULTS The dissolution of Nimesulide Granules had achieved 75% in 15 min.CONCLUSION This method is simple and satisfied for the determination of dissolution of Nimesulide Granules.

关 键 词：尼美舒利 颗粒剂 高效液相色谱法 

分 类 号：R917.101[医药卫生—药物分析学] R943.3[医药卫生—药学]