腹腔镜与开放手术治疗结直肠癌的肿瘤学安全性比较  

A Comparative Study of Oncology Safety between Laparoscopic Operation and Open Operation on Patients with Colorectal Tumor

作　　者：张定国[1] 阮金红[1] 阮秀丽[1] 

机构地区：[1]湖北省红安县人民医院外三科,438400

出　　处：《肿瘤防治研究》2008年第S1期12-13,17,共3页Cancer Research on Prevention and Treatment

摘　　要：目的评价腹腔镜结直肠癌手术的肿瘤学安全性。方法选取结直肠癌患者60例,分为腹腔镜手术组(LC)和开放手术组(OC)各30例,采用双抗体夹心酶联免疫方法(ELISA)检测术前和术后不同时期血清血管内皮生长因子(VEGF)、上皮钙粘素(E-Cadherin)水平,并比较两组间的差异。结果术后第7、10天OC组血清VEGF水平明显高于LC组,差异有统计学意义(P<0.01);而血清E-Cadherin水平LC组术后缓慢下降,至第10天达到最低值,OC组术后亦缓慢下降,至第3天又缓慢回升,第10天基本恢复术前水平,两组术后第10天血清E-Cadherin水平比较差异有统计学意义(P<0.01)。结论腹腔镜结直肠癌手术与传统开放手术比较,不会增加肿瘤转移的机会。Objective To study Safety of oncology on laparoscopy colorectal tumor surgery.Methods Sixty patients with colorectal tumor were randomized into LC group(laparoscopic colorectal operation) and OC(open colorectal operation),with 30 cases in each group.Enzyme linked immunosorbent assay(ELISA) was used to detect the level of vascular endothelial growth factor(VEGF) and E-cadherin in serum during the surgery.Results The serum VEGF level was significant high in the OC group than that in the LC group on postoperat...

关 键 词：腹腔镜 肿瘤 转移 VEGF E-CADHERIN 

分 类 号：R735.3[医药卫生—肿瘤]