不同剂量碘化钾对Balb/c小鼠垂体促甲状腺激素细胞的影响  

Effects of different Iodine concentrations on TSH cells in Balb/c mouse

作　　者：高伟[1] 刘皓[1] 郑丽娜[1] 李金茹[1] 陈祖培[2] 

机构地区：[1]天津医科大学组织胚肽学教研室,天津300070 [2]天津医科大学内分泌研究所,天津300070

出　　处：《解剖学研究》2008年第6期424-426,429,共4页Anatomy Research

基　　金：国家自然科学基金重点资助项目(30230330)

摘　　要：目的探讨不同剂量碘化钾对Balb/c小鼠垂体促甲状腺细胞的形态学影响。方法选用断乳后1个月,体重在16～20g的Balb/c小鼠,雌雄各半,随机分为4组:NI组、5HI组、10HI组、50HI组。饲养3个月后,股动脉放血处死动物。测定小鼠的血清甲状腺激素水平和垂体TSH细胞的体密度和面数密度。结果随着碘摄入量增加,TT4及FT4呈下降趋势,TT3及FT3明显降低,即高碘化钾摄入小鼠发生了甲状腺功能低下,形态学计量结果显示5HI、10HI、50HI组TSH阳性细胞的体密度和面数密度与NI组比较均无统计学意义。结论过量碘化钾(50HI)摄入不会引起小鼠垂体TSH细胞的形态学改变。Objective To explore the effects of different iodine concentrations on TSH cells in Balb / c mouse. Methods Balb / c mouse, 1 month after stopping lactation, were divided into 4 groups: normal iodine group (NI); 5, 10, 50 times of normal iodine groups (5HI, 10HI, 50HI). After 3 months, the concentration of thyroid hormones in the serum were measured and the volume density of TSH cells and the number of the strongly positive TSH cells were analyzed. Results Compared with those in the NI group, no significat ...

关 键 词：碘 垂体 促甲状腺激素细胞 甲状腺 

分 类 号：R361.2[医药卫生—病理学]