兔局灶脑缺血再灌注模型制作的质量控制和影像学评价  

Quality control for improving the successful rate of intraluminal thread approach in making focal cerebral ischemic reperfusion model in rabbits and evaluation of image features

作　　者：王志红[1] 刘怀军[2] 李林芳[2] 徐英进[2] 宋利宏[2] 赵林[2] 杨冀萍[2] 宋鹏[2] 孟江涛[2] 

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000 [2]河北医科大学第二医院影像科,石家庄050000

出　　处：《脑与神经疾病杂志》2008年第6期685-688,共4页Journal of Brain and Nervous Diseases

基　　金：河北省自然基金资助项目(c2006000927)

摘　　要：目的:探讨建立可控的量化指标,提高兔局灶脑缺血再灌注模型成功率。方法:健康新西兰白兔45只,随机分为3组:A组5只,为假手术对照组;B组10只,进行颈部动脉的CTA、DSA检查,造模成功后行解剖学测量;C组30只为缺血再灌注组,MCA阻塞时间分为7、15和30min3个亚组(n=10),造模成功后行DWI和PWI观察。结果:DSA、CTA可以清楚地显示兔颈动脉系统的走行特点及其分支情况,解剖学测量ICA及各段的长度,建立了可控的量化指标,模型成功率82.5%。结论:通过量化指标的建立提高了模型成功率和可操作性。Objective:Approach to establishment of controllable quantified index to improve the successful rate of intraluminal thread approach in making focal cerebral ischemic reperfusion model in rabbits.Methods:Forty-five New Zealand white rabbits were randomly divided into three groups :A,B and C.Group A(n=5)was sham-operated.In group B(n=10),CT angiography(CTA)and digital subtraction angiography(DSA)of carotid arteries were firstly performed to observe the gross morphology of carotid arteries,and then anatomical ...

关 键 词：兔 短暂性脑缺血 动物模型 

分 类 号：R74[医药卫生—神经病学与精神病学]