检测肺癌患者血清VEGF-C水平和纵隔淋巴结新生淋巴管的预后价值  

The prognostic value of detection of serum VEGF-C level and lymphangiogenesis in mediastinal lymph nodes in the patients with lung cancer

作　　者：申屠阳[1] 赵天成[2] 丁征平[1] 周允中[1] 

机构地区：[1]上海市胸科医院/上海市肺部肿瘤临床医学中心胸外科,上海200030 [2]上海市第六人民医院胸外科,上海200233

出　　处：《中国肺癌杂志》2008年第6期769-774,共6页Chinese Journal of Lung Cancer

基　　金：上海市卫生局科研基金(No.20060066)资助~~

摘　　要：背景与目的肺癌仍然缺乏特异性的预后指标,本研究拟探讨检测肺癌患者血清VEGF-C和病灶/纵隔淋巴结新生淋巴管对患者生存率的预后价值。方法分别选取30例新手术(新入组)和30例术后(历史组)已随访3年的肺癌患者,测定新入组术前血清VEGF-C水平,检测两组病灶/纵隔淋巴结VEGF-C/LYVE-1的表达。分析血清VEGF-C水平、病灶/纵隔淋巴结VEGF-C/LYVE-1表达、纵隔淋巴结转移和生存率等指标之间的相关性。结果①新入组纵隔淋巴结转移患者血清VEGF-C水平显著高于无转移者。②新入组血清VEGF-C水平与病灶VEGF-C表达强度呈高度相关。③两组病灶及纵隔转移淋巴结VEGF-C均高度表达。④两组病灶/纵隔淋巴结VEGF-C表达与LYVE-1表达均显著相关。⑤纵隔淋巴结转移者病灶/纵隔淋巴结的VEGF-C/LYVE-1表达显著高于无转移者。⑥历史组病灶VEGF-C表达和纵隔淋巴结转移与术后3年生存率有明显关联。结论血清VEGF-C水平与病灶VEGF-C表达、病灶/纵隔淋巴结新生淋巴管、纵隔淋巴结转移状态和生存率有较好的相关性,或可作为肺癌预后的指标。Background and objective There is still lack of special prognostic factor on lung cancer,this study will explore the prognostic value of serum VEGF-C level and lymphangiogenesis of primary cancer and mediastinal lymph nodes in the patients with lung cancer.Methods Thirty patients with NSCLC would accept operation(new group) and 30 cases followed up three years postoperative(history group) were chosen respectively.The serum VEGF-C level of new group was tested.The VEGF-C and LYVE-1 expression in the mediasti...

关 键 词：肺肿瘤 VEGF-C 新生淋巴管 预后 

分 类 号：R734.2[医药卫生—肿瘤]