DNA-PKcs在鼻咽癌组织中的表达及临床相关性研究  

Expression of DNA-PKcs in nasopharyngeal carcinoma tissue and its clinical significance

作　　者：侯宇[1] 李文辉[1] 杨胜刚[1] 秦继勇[1] 夏群[1] 

机构地区：[1]昆明医学院第三附属医院(云南省肿瘤医院)放疗科,云南昆明650118

出　　处：《现代肿瘤医学》2008年第11期1878-1881,共4页Journal of Modern Oncology

基　　金：云南省教育厅立项课题(编号:5z03210)

摘　　要：目的:研究DNA-PKcs蛋白的表达与鼻咽癌各临床指标的相关性,探寻DNA-PKcs的表达与鼻咽癌放射敏感性的关系。方法:应用免疫组化法测定65例鼻咽低分化鳞癌DNA-PKcs蛋白的表达。结果:DNA-PKcs的表达在原发灶退缩情况、性别、患病年龄、原发灶大小、淋巴结转移等观察指标中其差异未见有统计学意义;II期+III期病例,与IVa期病例相比较,DNA-PKcs表达的差异有统计学意义(P=0.027);癌组织与癌旁正常组织DNA-PKcs的表达差异未见有统计学意义。结论:鼻咽癌组织中DNA-PKcs蛋白的表达与放疗后原发灶退缩情况无关,提示与鼻咽癌放射敏感性无确切相关性;该蛋白的表达与临床分期有一定关系;鼻咽癌癌组织与癌旁正常组织DNA-PKcs蛋白的表达具有一致性。Objective:To study the DNA-PKcs protein expression and its clinical significance in nasopharyngeal carcinoma.Methods: The expression of DNA-PKcs was determined by immunohistochemical technique.Results: There were no differences of DNA-PKcs protein expression for observed clinical index,except for stage IVa and stage II+III(P=0.027).The protein expression was no difference between carcinoma tissue and normal tissue.Conclusion: The expression of DNA-PKcs has no relationship with radiosensitivity in NPC;There ...

关 键 词：鼻咽癌 放射治疗 DNA依赖蛋白激酶(DNA-PK) 免疫组化 放射敏感性 

分 类 号：R739.63[医药卫生—肿瘤]