S100A8和S100A9在子宫颈鳞癌组织中的表达  

Expression of S100A8 and S100A9 in cervical squamous cell carcinoma

作　　者：冯旺琴[1] 崔竹梅[2] 刘芝华[3] 李玉军[2] 

机构地区：[1]首都医科大学附属北京妇产医院妇产科,北京100026 [2]青岛大学医学院附属医院,山东青岛266003 [3]中国医学科学院中国协和医科大学肿瘤研究所分子肿瘤学国家重点实验室,北京100021

出　　处：《现代肿瘤医学》2008年第11期1969-1972,共4页Journal of Modern Oncology

摘　　要：目的:探讨S100A8、S100A9在子宫颈鳞癌及正常宫颈组织中的表达及其意义。方法:采用半定量的RT-PCR技术和免疫组织化学的方法,从mRNA及蛋白水平检测32例子宫颈鳞癌和15例正常宫颈组织中S100A8、S100A9的表达,及与不同临床病理参数的关系。结果:子宫颈鳞癌组织中,S100A8、S100A9在mRNA及蛋白水平上均低表达(P<0.05),其中,低分化肿瘤的表达明显低于高、中分化肿瘤(P<0.05)。结论:S100A8、S100A9在子宫颈鳞癌组织中低表达,且可能与鳞状细胞的分化程度相关。提示S100A8、S100A9低表达可能与子宫颈鳞癌的发生发展有关系。Objective:To investigate the expression of S100A8 and S100A9 in squamous cell carcinoma of the uterine cervix and its significance.Methods:Archival specimens of squamous cell carcinoma of the uterine cervix(n=32) were included in the analysis compared with normal cervical squamous epithelium(n=15).The expression level of S100A8 and S100A9 mRNA and protein were examined by semi-quantitative RT-PCR and immunohistochemistry.and compared S100A8 and S100A9 expression in different clinicopathological cervical squ...

关 键 词：宫颈肿瘤 鳞癌 S100A8 S100A9 RT-PCR 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]