脑梗死患者的亚临床炎症及胰岛素抵抗  

Sub-clinical inflammation and insulin resistance in patients with cerebral infarction

作　　者：李世英[1] 闫冰[2] 臧贺川[1] 郭静[3] 

机构地区：[1]华北煤炭医学院附属医院神经内科,唐山市063000 [2]华北煤炭医学院附属医院血液科,唐山市063000 [3]华北煤炭医学院实验中心

出　　处：《临床神经病学杂志》2008年第6期416-418,共3页Journal of Clinical Neurology

摘　　要：目的观察脑梗死患者的亚临床炎症及胰岛素抵抗(IR)情况。方法检测114例脑梗死患者(脑梗死组)血清C-反应蛋白(CRP)、白介素-6(IL-6)及空腹胰岛素(Fins)、空腹血糖(FPG)、血脂、血压水平,分析胰岛素敏感指数(ISI)与炎症指标的关系,并与70例非脑梗死患者(对照组)进行比较。结果⑴脑梗死组血清CRP水平[(2.73±0.87)mg/L]、IL-6水平[(0.14±0.03)ng/ml]明显高于对照组[(1.63±0.93)mg/L、(0.12±0.03)ng/ml](均P<0.01),ISI(-4.31±0.53)明显低于对照组(-3.92±0.43)(P<0.01);⑵脑梗死组中,CRP>8.2mg/L患者的ISI(-4.63±0.71)明显低于CRP≤8.2mg/L患者的ISI(-4.18±0.54)(P<0.05)。结论脑梗死患者存在血清炎症的证据及IR;并且IR和亚临床炎症反应水平相一致。Objective To observe the sub-clinical inflammation and insulin resistance (IR) in patients with cerebral infarction(CI). Methods The levels of serum C-reactive protein (CRP),interleukin-6 (IL-6),fasting insulin (Fins),fasting plasma glucose (FPG),blood lipids and blood pressure were measured in 114 patients with CI (CI group). The insulin sensitivity index (ISI) was observed and the correlation between ISI and indexes of inflammation were analysed. The results were compared with 70 patients without CI(contr...

关 键 词：脑梗死 炎症 胰岛素抵抗 C-反应蛋白 白介素-6 

分 类 号：R743.33[医药卫生—神经病学与精神病学]